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Squalane is the hydrogenated (stable) form of squalene, a lipid that human sebaceous glands naturally produce. Squalene makes up about 12% of human sebum. The hydrogenation process saturates the double bonds, preventing oxidation and giving squalane an indefinite shelf life. It is sourced from olives, sugarcane, or rice bran (plant-derived) or from shark liver (animal-derived, now rare in K-beauty). Squalane spreads easily, absorbs without greasiness, and reinforces the skin's lipid barrier.
Squalane integrates into the intercellular lipid matrix of the stratum corneum because its structure closely matches human skin lipids. It fills gaps between corneocytes, reducing transepidermal water loss without forming a heavy occlusive film the way petrolatum does. Its molecular weight (~423 Da) allows it to penetrate the upper layers of the epidermis rather than just sitting on the surface. This makes it an emollient (softens skin) and a mild occlusive (prevents water loss) in one molecule.
Barrier repair and moisture retention
Squalane reduced TEWL and increased stratum corneum hydration in a 4-week study of 20 subjects with dry skin. Its structural similarity to native skin lipids allows it to integrate into the barrier more effectively than plant oils with different fatty acid profiles.
Huang et al., 2009 — Journal of Cosmetic Dermatology
Non-comedogenic moisturization
Squalane has a comedogenicity rating of 0-1 on the 0-5 scale, meaning it does not clog pores in standard rabbit ear assays. Clinical use confirms this — squalane is well tolerated on oily, acne-prone skin when applied in thin layers.
Draelos, 2012 — Journal of Cosmetic Dermatology
Antioxidant protection
Squalene (the unsaturated precursor) is a potent lipid-soluble antioxidant in human skin, scavenging singlet oxygen generated by UV exposure. While squalane is less reactive than squalene due to hydrogenation, it still contributes to the lipid antioxidant pool in the stratum corneum.
Kohno et al., 1995 — Biochimica et Biophysica Acta
Improved absorption of other actives
Squalane acts as a penetration enhancer for lipophilic compounds. When mixed with retinol or vitamin E, squalane increases their delivery into the upper epidermis by disrupting lipid packing in the stratum corneum without causing irritation.
Pham et al., 2016 — International Journal of Pharmaceutics
Aqua Squalane Moisturizing Cream
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Aqua Squalane Serum
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Pure Cleansing Oil Deep Clean
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Squalane works on every skin type. Oily and acne-prone skin tolerate it because it is non-comedogenic and absorbs fast — 2-3 drops patted into damp skin leave no oily residue. Dry skin benefits from its barrier-reinforcing properties but may need a heavier cream on top for full occlusion. Sensitive skin tolerates squalane well because it is a pure hydrocarbon with no fragrance, no active acids, and no protein components to trigger reactions.
Pure squalane oil (100%) is used as a standalone product — 2-4 drops mixed into a moisturizer or applied after serum. In formulated products (serums, creams, emulsions), squalane typically appears at 5-20% of the formula. Higher concentrations increase the emollient effect. Plant-derived squalane from olives or sugarcane is chemically identical to shark-derived squalane. Check the source if you prefer to avoid animal-derived ingredients.
Hyaluronic acid
HA pulls water into the epidermis; squalane seals it there with a lightweight lipid layer. Apply HA to damp skin first, then 2-3 drops of squalane on top. This gives both humectant and emollient coverage.
Retinol
Squalane buffers retinol irritation by reinforcing the lipid barrier and acts as a penetration enhancer that improves retinol delivery. Mixing a drop of squalane into your retinol product can reduce flaking during the adjustment period.
Ceramides
Squalane and ceramides address different lipid classes in the barrier — squalane replaces lost sebum components, ceramides replace structural lipids between corneocytes. Together they rebuild the full lipid barrier.
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